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- Fenfluramine (Pondimin), used in the combination drug fen-phen (fenfluramine/phentermine) was associated with dangerous heart valve side effects and is no longer available due to this side effect. Fenfluramine inhibits serotonin reuptake to reduce appetite. In 1997, the FDA withdrew fenfluramine and dexfenfluramine (Redux) from the U.S. market.
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In December 2015, the FDA recalled over a dozen products marketed by Bee Extremely Amazed LLC, of Jewett, OH. These products were also found to contain sibutramine and phenolphthalein, both products removed from the US market due to serious safety concerns, including heart side effects and cancer.
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- U.S. Department of Health and Human Services. National Institutes of Health. National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK). Prescription Medications to Treat Overweight and Obesity. Accessed October 21, 2016. https://www.niddk.nih.gov/health-information/health-topics/weight-control/prescription-medications-treat-overweight-obesity/Pages/facts.aspx
- U.S. Food and Drug Administration. Questions and Answers: FDA Recommends Against the Continued Use of Meridia (sibutramine). Accessed October 21, 2016 at http://www.fda.gov/Drugs/DrugSafety/ucm228747.htm
- Yanovski SZ, Yanovski JA. JAMA. Long-term drug treatment for obesity: A systematic and clinical review. 2014; 311(1):74–86
- U.S. Food and Drug Administration. Beware of Fraudulent Weight-Loss 'Dietary Supplements'. Accessed October 21, 2016 at https://www.drugs.com/fda-consumer/beware-of-fraudulent-weight-loss-dietary-supplements-176.html
- FDA-Approved Weight Loss Drugs: Can They Help You? Drugs.com Accessed October 21, 2016 at https://www.drugs.com/slideshow/fda-approved-weight-loss-drugs-1044
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